Our technology
Innovative purification platforms built for industrial reality
ASKLEIA's technologies address the core economic and operational constraints of biomolecule purification. Our technology is designed to be adaptable, transferable and scalable.
Y Serie
Selective Continuous Precipitation
Continuous precipitation is achieved by micro-mixing the crude feedstock with a precipitating agent, which removes some of the contaminants in solid form. The specific design service broadens the scope of application of the technology and increases its effectiveness.
A home-designed device ensures controlled and reproducible processes. Combined with depth or tangential filtration flow, Askleia technology makes it possible to separate the protein of interest from some of the impurities.
F Serie
Continuous Free-flow Electrophoresis
Free-flow electrophoresis (FFE) is a free-flow separation method that uses an electric field to separate molecules. Depending on their electrophoretic mobility (charge and size), molecules are deflected to a greater or lesser extent by the electric field.
Compared to conventional FFE techniques, limited to analytical testing, the innovations of the ASKLEIA FFE chip enable industrial-scale production:
• Reduced bubble formation thanks to liquid electrodes
• Heating problems controlled
• Reproducibility and very high specificity
• Drastic reduction in buffer consumption with significantly reduced environmental footprint
Technology Objective
Designed around the molecular problem, not the existing toolbox
ASKLEIA's approach is rooted in a deep understanding of the physicochemical properties governing biomolecule behaviour during separation.
From first principles (trouver visuel)
Rather than adapting existing purification hardware to new molecules, our technologies are engineered from first principles — targeting the specific binding, selectivity, and elution mechanisms that matter most for each molecule class. This allows us to achieve high purity with significantly fewer operational steps.
Industrial transferability (trouver visuel)
ASKLEIA technologies are designed with industrial transferability as a core constraint. Every process decision is evaluated not only for scientific performance but for practical implementability — equipment compatibility, regulatory readiness, raw material availability, and cost at volume.
Competitive Differentiation
ASKLEIA vs Conventional Chromatography
| Criteria | Conventional | ASKLEIA |
|---|---|---|
| Ligand cost | High (Protein A) | Reduced |
| Resin cost | High | No resin |
| Number of steps | 3–5 | 1–2 |
| Buffer consumption | High | Significantly reduced |
| Organic solvent | High | No solvent |
| Scale-up complexity | — | ✓ |
| Process flexibility | — | ✓ |
| Mode of operation | Batch or semi-batch | Continuous-compatible |
| Scale of equipment | Large | Compact |
| Resin fouling | Frequent | — |
| Resin regeneration | Frequent | — |
| Footprint | Large | Limited |
Contact :
Hours: 9 a.m. – 5 p.m., Monday to Friday
Phone: +33 4 42 01 90 59
Address: 510 Avenue de Jouques, Pôle Performance, Building C2, 13400 Aubagne
